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Harnessing the therapeutic potential of targeted phosphatase activity

Our lab combines imaging with proteomics in a dual strategy approach to map the dynamic targeting of protein phosphatase 1 (PP1) to its diverse range of substrates throughout the cell cycle and in response to perturbations such as stress or DNA damage. The end goal is to design novel therapeutic strategies that target its activity with high specificity and thus minimal off-target effects. 

Check out Ikram's 1 minute video on stress response pathways!

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