Harnessing the therapeutic potential of targeted phosphatase activity

Our lab combines imaging with proteomics in a dual strategy approach to map the dynamic targeting of protein phosphatase 1 (PP1) to its diverse range of substrates throughout the cell cycle and in response to perturbations such as stress or DNA damage. The end goal is to design novel therapeutic strategies that target its activity with high specificity and thus minimal off-target effects.  

Department of Cellular & Molecular Medicine

Ottawa Institute of Systems Biology

University of Ottawa

Ottawa, Canada

© 2019 by L Trinkle-Mulcahy
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